The Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Signaling, Tumorigenesis and Metastasis

As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to medi...

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Bibliographic Details
Published in:Cancers 2021-04, Vol.13 (9), p.2005
Main Authors: Erfani, Sonia, Hua, Hui, Pan, Yueyin, Zhou, Binhua P, Yang, Xiuwei H
Format: Article
Language:English
Subjects:
Angiogenesis
Breast
Breast cancer
Cell adhesion & migration
Cell lineage
Colon
Diagnosis
Epigenetics
Gene amplification
Glioblastoma
Kinases
Malignancy
Membrane proteins
Mesenchyme
Metabolism
Metastases
Metastasis
Motility
Mutation
Ovarian carcinoma
Ovaries
Plasticity
Prostate
Prostate carcinoma
Review
Signal transduction
Skin cancer
Stem cells
Tumor cells
Tumorigenesis
Tumors
Wnt protein
β-Catenin
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Summary:As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context- and cell lineage-dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin-associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), and the Wnt/β-catenin pathway, as well as the dynamics of exosome and cellular metabolism. Finally, we discuss the implications of the highly plastic nature and epigenetic susceptibility of CD151 expression, function, and signaling for clinical diagnosis and therapeutic intervention for human cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13092005