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Saliva Gene Promoter Hypermethylation as a Biomarker in Oral Cancer

Oral carcinogenesis is a multistep process characterized by a summation of multiple genetic and epigenetic alterations in key regulatory genes. The silencing of genes by aberrant promoter hypermethylation is thought to be an important epigenetic event in cancer development and progression which has...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-04, Vol.10 (9), p.1931
Main Authors: Rapado-González, Óscar, López-Cedrún, José Luis, López-López, Rafael, Rodríguez-Ces, Ana María, Suárez-Cunqueiro, María Mercedes
Format: Article
Language:English
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Summary:Oral carcinogenesis is a multistep process characterized by a summation of multiple genetic and epigenetic alterations in key regulatory genes. The silencing of genes by aberrant promoter hypermethylation is thought to be an important epigenetic event in cancer development and progression which has great potential as a biomarker for early diagnosis, tumor molecular subtyping, prognosis, monitoring, and therapy. Aberrant DNA methylation has been detected in different liquid biopsies, which may represent a potential alternative to solid biopsies. The detection of methylated genes in saliva may have clinical application for noninvasive oral cancer screening and early diagnosis. Here, we review the current evidence on gene promoter hypermethylation in saliva.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10091931