Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function,...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-05, Vol.18 (9), p.4956
Main Authors: Malamba-Lez, Didier, Tshala-Katumbay, Désire, Bito, Virginie, Rigo, Jean-Michel, Kipenge Kyandabike, Richie, Ngoy Yolola, Eric, Katchunga, Philippe, Koba-Bora, Béatrice, Ngoy-Nkulu, Dophra
Format: Article
Language:English
Subjects:
Antimony
Arsenic
Barium
Blood
Cadmium
Cardiomyopathy
Cardiomyopathy, Dilated - chemically induced
Cardiomyopathy, Dilated - epidemiology
Cardiovascular disease
Case-Control Studies
Chromium
Chronic illnesses
Copper
Creatinine
Democratic Republic of the Congo - epidemiology
Dilated cardiomyopathy
Ejection fraction
Electrocardiography
Environmental Exposure - analysis
Exposure
Generalized linear models
Heart failure
Heavy metals
Humans
Hypertension
Medical tests
Metals, Heavy
Potassium
Public health
Renal function
Selenium
Software
Statistical analysis
Thallium
Toxicity
Uranium
Uric acid
Urine
Zambia
Zinc
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Summary:Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18094956