The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of t...

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Bibliographic Details
Published in:Materials 2021-05, Vol.14 (9), p.2449
Main Authors: Kaczmarek-Szczepańska, Beata, Mazur, Olha, Michalska-Sionkowska, Marta, Łukowicz, Krzysztof, Osyczka, Anna Maria
Format: Article
Language:English
Subjects:
Acids
Chitosan
Crosslinking
Dental materials
Erythrocytes
Hydrogels
Mechanical properties
Molecular weight
Physiology
Polyphenols
Stability analysis
Tannic acid
Thermal stability
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Summary:In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma14092449