Cerebral Venous Thrombus Signal Intensity and Susceptibility Effects on Gradient Recalled-Echo MR Imaging

Cerebral venous thrombus (CVT) signal intensity is variable on MR imaging, and the appearance of CVT on gradient recalled-echo (GRE) sequences has been incompletely assessed. This study was performed to evaluate the GRE imaging appearance of CVT in different stages of thrombus evolution and its rela...

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Bibliographic Details
Published in:American Journal of Neuroradiology 2007-05, Vol.28 (5), p.940-945
Main Authors: Leach, J.L, Strub, W.M, Gaskill-Shipley, M.F
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Brain
Cerebral Veins - pathology
Databases, Factual
Disease Progression
Female
Humans
Intracranial Thrombosis - pathology
Intracranial Thrombosis - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
Nervous system
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radionuclide investigations
Venous Thrombosis - pathology
Venous Thrombosis - physiopathology
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Summary:Cerebral venous thrombus (CVT) signal intensity is variable on MR imaging, and the appearance of CVT on gradient recalled-echo (GRE) sequences has been incompletely assessed. This study was performed to evaluate the GRE imaging appearance of CVT in different stages of thrombus evolution and its relationship to signal intensity on other MR pulse sequences. The clinical and MR imaging findings in 18 patients with CVT and GRE imaging were reviewed. Sixty-nine thrombosed venous segments were evaluated, and the signal intensity of thrombus relative to gray matter was determined. The degree of thrombus susceptibility effect (SE) was assessed and related to time of imaging after onset of symptoms (clinical thrombus age) and appearance on other pulse sequences. Segments were classified as SE+ (demonstrating susceptibility effect) or SE- (no susceptibility effect). Thirty-six venous segments exhibited visible SE. SE+ segments had a clinical thrombus age that was less than that in SE- segments (8.1 versus 24.6 days, P=.003). Sixty-three percent (23/36) of SE+ segments exhibited hypointensity on T2-weighted images (T2WI) versus 12% (4/33) of SE- segments (P
ISSN:0195-6108
1936-959X
1432-1920