Clinicopathological characteristics of pancreatic ductal adenocarcinoma with invasive micropapillary carcinoma component with emphasis on the usefulness of PKCζ immunostaining for detection of reverse polarity

Invasive micropapillary carcinoma (IMPC) is a rare distinct histopathological subtype, characterized by the presence of carcinoma cells displaying reverse polarity. Only limited clinicopathological information is available regarding pancreatic IMPC. The aim of the present study was to clarify the cl...

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Bibliographic Details
Published in:Oncology letters 2021-07, Vol.22 (1), p.525-525, Article 525
Main Authors: Ryota, Hironori, Ishida, Mitsuaki, Ebisu, Yusuke, Yanagimoto, Hiroaki, Yamamoto, Tomohisa, Kosaka, Hisashi, Hirooka, Satoshi, Yamaki, So, Kotsuka, Masaya, Matsui, Yoichi, Tsuta, Koji, Satoi, Sohei
Format: Article
Language:English
Subjects:
Antigens
Kinases
Lymphatic system
Medical prognosis
Metastasis
Monoclonal antibodies
Neutrophils
Pancreas
Pancreatic cancer
Proteins
Signal transduction
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Summary:Invasive micropapillary carcinoma (IMPC) is a rare distinct histopathological subtype, characterized by the presence of carcinoma cells displaying reverse polarity. Only limited clinicopathological information is available regarding pancreatic IMPC. The aim of the present study was to clarify the clinicopathological features of pancreatic IMPC and the usefulness of protein kinase C (PKC)ζ immunostaining for the detection of reverse polarity. We reviewed 242 consecutive surgically resected specimens of pancreatic ductal adenocarcinoma and selected samples with an IMPC component. Clinicopathological characteristics were compared between the IMPC and non-IMPC groups. Immunohistochemical staining for PKCζ was performed using an autostainer. In total, 14 cases had an IMPC component (5.8%). The extent of IMPC component ranged from 5 to 20%. There were no significant differences in tumor location, T category, lymph node metastatic status, preoperative carbohydrate antigen 19-9 level, resection status and overall survival between the IMPC and non-IMPC groups. Immunostaining for PKCζ clearly showed reverse polarity of the neoplastic cells of IMPC. Although previous reports have shown that the presence of an IMPC component (>20% of the tumor) indicated poor prognosis, the present study demonstrated that presence of IMPC
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2021.12786