Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging

The brain functions through coordinated activity among distributed regions. Wide-field calcium imaging, combined with improved genetically encoded calcium indicators, allows sufficient signal-to-noise ratio and spatiotemporal resolution to afford a unique opportunity to capture cortex-wide dynamics...

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Bibliographic Details
Published in:The Journal of neuroscience 2021-05, Vol.41 (19), p.4160-4168
Main Authors: Ren, Chi, Komiyama, Takaki
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium imaging
Calcium signalling
Cerebral Cortex - diagnostic imaging
Circuits
Cognitive ability
Decision making
Dynamics
Genetic code
Humans
Imaging
Neuroimaging
Neuroimaging - methods
Sensorimotor integration
Signal to noise ratio
Task complexity
TechSights
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Summary:The brain functions through coordinated activity among distributed regions. Wide-field calcium imaging, combined with improved genetically encoded calcium indicators, allows sufficient signal-to-noise ratio and spatiotemporal resolution to afford a unique opportunity to capture cortex-wide dynamics on a moment-by-moment basis in behaving animals. Recent applications of this approach have been uncovering cortical dynamics at unprecedented scales during various cognitive processes, ranging from relatively simple sensorimotor integration to more complex decision-making tasks. In this review, we will highlight recent scientific advances enabled by wide-field calcium imaging in behaving mice. We then summarize several technical considerations and future opportunities for wide-field imaging to uncover large-scale circuit dynamics.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.3003-20.2021