Functions and Targets of miR-335 in Cancer

MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in can...

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Published in:OncoTargets and therapy 2021-01, Vol.14, p.3335-3349
Main Authors: Ye, Lingling, Wang, Fen, Wu, Hao, Yang, Hui, Yang, Yan, Ma, Yajun, Xue, Aili, Zhu, Jing, Chen, Meili, Wang, Jinyan, Zhang, Quan an
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Bladder cancer
Bone cancer
Breast cancer
Cancer
Cell cycle
Cell growth
Cervical cancer
Development and progression
Esophageal cancer
Gene expression
Genes
Kinases
Lung cancer
Lymphatic system
Medical prognosis
Melanoma
Metastases
Metastasis
MicroRNA
MicroRNAs
miRNA
Non-coding RNA
Oncology, Experimental
Ovarian cancer
Pancreatic cancer
Prostate cancer
Proteins
Review
Thyroid cancer
Tumor microenvironment
Tumor suppressor genes
Tumors
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Summary:MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also influences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors. Keywords: miR-335 cancer, prognosis, tumor biology, regulation
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S305098