Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat

Purpose. The aim of this study was to evaluate the effect of lycopene on hypoxia-induced testicular injury in rat model and explore the underlying mechanism. Methods. Six-week-old male Wistar rats (n = 36) were randomly divided into three groups (n = 12/group): a normal group (NG, sham control), a v...

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Published in:Evidence-based complementary and alternative medicine 2021, Vol.2021, p.3471356-8
Main Authors: Wang, Hongqiang, Zhu, Baojuan, Yu, Lei, Li, Qiang, Li, Shenqian, Wang, Peitao, Jing, Tao, Men, Tongyi
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Alternative medicine
Animal models
Apoptosis
Biotechnology industry
Experiments
Hypoxia
IL-1β
Infertility
Interleukin 2
Lycopene
Medical research
NF-κB protein
Oxidative stress
Proliferating cell nuclear antigen
Proteins
Rodents
Sex hormones
Sperm
Spermatogenesis
Testes
TOR protein
Vascular endothelial growth factor
Veins & arteries
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Summary:Purpose. The aim of this study was to evaluate the effect of lycopene on hypoxia-induced testicular injury in rat model and explore the underlying mechanism. Methods. Six-week-old male Wistar rats (n = 36) were randomly divided into three groups (n = 12/group): a normal group (NG, sham control), a varicocele group (VG), and a varicocele treated by lycopene group (VLG). Bilateral renal veins constriction was performed on rats in VG and VLG. Simultaneously, rats in VLG were treated to lycopene by intragastric administration. Four weeks later, sperm was collected for sperm analysis. Testes and epididymides were harvested for morphological change analysis, histologic analysis, ELISA, qRT-PCR, and western blot. Results. Our observations were that lycopene improved the hypoxia-induced testicular injury in vivo. Prokineticin 2(PROK2) and prokineticin receptor 2 (PROKR2) were overexpressed in VG (P 
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/3471356