Analysis of Skin Pigmentation and Genetic Ancestry in Three Subpopulations from Pakistan: Punjabi, Pashtun, and Baloch

Skin pigmentation is one of the most prominent and variable phenotypes in humans. We compared the alleles of 163 SNPs and indels from the Human Pigmentation (HuPi) AmpliSeq™ Custom panel, and biogeographic ancestry with the quantitative skin pigmentation levels on the upper arm, lower arm, and foreh...

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Bibliographic Details
Published in:Genes 2021-05, Vol.12 (5), p.733
Main Authors: Shan, Muhammad Adnan, Meyer, Olivia Strunge, Refn, Mie, Morling, Niels, Andersen, Jeppe Dyrberg, Børsting, Claus
Format: Article
Language:English
Subjects:
Biogeography
Criminal investigations
Genetic analysis
Genetic distance
Genetics
Genomes
Genotype & phenotype
Phenotypes
Population
Principal components analysis
Single-nucleotide polymorphism
Skin
Skin pigmentation
Software
Subpopulations
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Summary:Skin pigmentation is one of the most prominent and variable phenotypes in humans. We compared the alleles of 163 SNPs and indels from the Human Pigmentation (HuPi) AmpliSeq™ Custom panel, and biogeographic ancestry with the quantitative skin pigmentation levels on the upper arm, lower arm, and forehead of 299 Pakistani individuals from three subpopulations: Baloch, Pashtun, and Punjabi. The biogeographic ancestry of each individual was estimated using the Precision ID Ancestry Panel. All individuals were mainly of mixed South-Central Asian and European ancestry. However, the Baloch individuals also had an average proportion of Sub-Saharan African ancestry of approximately 10%, whereas it was
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12050733