Sex-specific genetic architecture in response to American and ketogenic diets

Background/objectives There is a growing appreciation for individual responses to diet. In a previous study, mouse strain-specific responses to American and ketogenic diets were observed. In this study, we searched for genetic variants underlying differences in the responses to American and ketogeni...

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Bibliographic Details
Published in:International Journal of Obesity 2021-06, Vol.45 (6), p.1284-1297
Main Authors: Salvador, Anna C., Arends, Danny, Barrington, William T., Elsaadi, Ahmed M., Brockmann, Gudrun A., Threadgill, David W.
Format: Article
Language:English
Subjects:
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Adipose Tissue - metabolism
Adipose Tissue - physiology
Animals
Body composition
Body fat
Carbohydrate composition
Carbohydrates
Cholesterol
Diet
Diet, Ketogenic
Diet, Western
Epidemiology
Gene mapping
Genetic aspects
Genetic diversity
Genetic variance
Health Promotion and Disease Prevention
High density lipoprotein
Identification and classification
Internal Medicine
Ketogenic diet
Medicine
Medicine & Public Health
Metabolic Diseases
Mice
Nutrition
Physiological aspects
Physiological responses
Public Health
Quantitative trait loci
Quantitative Trait Loci - genetics
Sex
Sex Factors
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Summary:Background/objectives There is a growing appreciation for individual responses to diet. In a previous study, mouse strain-specific responses to American and ketogenic diets were observed. In this study, we searched for genetic variants underlying differences in the responses to American and ketogenic diets between C57BL/6J (B6) and FVB/NJ (FVB) mouse strains. Results Genetic mapping of fat and lean mass gain revealed QTLs on Chromosome (Chr) 1 at 191.6 Mb ( Fmgq1 ) ( P  
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-021-00785-7