A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia

During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia pla...

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Bibliographic Details
Published in:Journal of natural medicines 2021-06, Vol.75 (3), p.449-466
Main Authors: Morikawa, Toshio, Ninomiya, Kiyofumi, Tanabe, Genzoh, Matsuda, Hisashi, Yoshikawa, Masayuki, Muraoka, Osamu
Format: Article
Language:English
Subjects:
Animals
Antidiabetics
Biological products
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Diabetes
Diabetes mellitus
Diabetes Mellitus - drug therapy
Diabetes Mellitus - prevention & control
Dietary supplements
Flowers & plants
Functional foods & nutraceuticals
Humans
Hypoglycemic Agents - pharmacology
Japan
Medicinal Chemistry
Medicinal plants
Medicine, Ayurvedic
Molecular Structure
Obesity - prevention & control
Pharmacology/Toxicology
Pharmacy
Plant Roots - chemistry
Plant Sciences
Plant Stems - chemistry
Randomized Controlled Trials as Topic
Review
Salacia
Salacia - chemistry
Sugar Alcohols - pharmacology
Sulfates - pharmacology
Thiosugars - pharmacology
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Summary:During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia , from basic chemical and pharmacological research to their application and development as new functional food ingredients. Graphic abstract
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01522-0