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A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia pla...
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| Published in: | Journal of natural medicines 2021-06, Vol.75 (3), p.449-466 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c591t-890bae8352935610df7404fc5aebe8e6ebf5f4c3a6481c878d9ab05b76f6cc023 |
| container_end_page | 466 |
| container_issue | 3 |
| container_start_page | 449 |
| container_title | Journal of natural medicines |
| container_volume | 75 |
| creator | Morikawa, Toshio Ninomiya, Kiyofumi Tanabe, Genzoh Matsuda, Hisashi Yoshikawa, Masayuki Muraoka, Osamu |
| description | During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (
1
) and neokotalanol (
4
), and related thiosugar sulfoniums, from the roots and stems of the genus
Salacia
plants [Celastraceae (Hippocrateaceae)] such as
Salacia reticulata
Wight,
S. oblonga
Wall., and
S. chinensis
L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus
Salacia
, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
Graphic abstract |
| doi_str_mv | 10.1007/s11418-021-01522-0 |
| format | article |
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1
) and neokotalanol (
4
), and related thiosugar sulfoniums, from the roots and stems of the genus
Salacia
plants [Celastraceae (Hippocrateaceae)] such as
Salacia reticulata
Wight,
S. oblonga
Wall., and
S. chinensis
L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus
Salacia
, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
Graphic abstract</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-021-01522-0</identifier><identifier>PMID: 33900535</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Animals ; Antidiabetics ; Biological products ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - prevention & control ; Dietary supplements ; Flowers & plants ; Functional foods & nutraceuticals ; Humans ; Hypoglycemic Agents - pharmacology ; Japan ; Medicinal Chemistry ; Medicinal plants ; Medicine, Ayurvedic ; Molecular Structure ; Obesity - prevention & control ; Pharmacology/Toxicology ; Pharmacy ; Plant Roots - chemistry ; Plant Sciences ; Plant Stems - chemistry ; Randomized Controlled Trials as Topic ; Review ; Salacia ; Salacia - chemistry ; Sugar Alcohols - pharmacology ; Sulfates - pharmacology ; Thiosugars - pharmacology</subject><ispartof>Journal of natural medicines, 2021-06, Vol.75 (3), p.449-466</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-890bae8352935610df7404fc5aebe8e6ebf5f4c3a6481c878d9ab05b76f6cc023</citedby><cites>FETCH-LOGICAL-c591t-890bae8352935610df7404fc5aebe8e6ebf5f4c3a6481c878d9ab05b76f6cc023</cites><orcidid>0000-0003-2794-5365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33900535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morikawa, Toshio</creatorcontrib><creatorcontrib>Ninomiya, Kiyofumi</creatorcontrib><creatorcontrib>Tanabe, Genzoh</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><creatorcontrib>Yoshikawa, Masayuki</creatorcontrib><creatorcontrib>Muraoka, Osamu</creatorcontrib><title>A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (
1
) and neokotalanol (
4
), and related thiosugar sulfoniums, from the roots and stems of the genus
Salacia
plants [Celastraceae (Hippocrateaceae)] such as
Salacia reticulata
Wight,
S. oblonga
Wall., and
S. chinensis
L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus
Salacia
, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
Graphic abstract</description><subject>Animals</subject><subject>Antidiabetics</subject><subject>Biological products</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Dietary supplements</subject><subject>Flowers & plants</subject><subject>Functional foods & nutraceuticals</subject><subject>Humans</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Japan</subject><subject>Medicinal Chemistry</subject><subject>Medicinal plants</subject><subject>Medicine, Ayurvedic</subject><subject>Molecular Structure</subject><subject>Obesity - prevention & control</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Roots - chemistry</subject><subject>Plant Sciences</subject><subject>Plant Stems - chemistry</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>Salacia</subject><subject>Salacia - chemistry</subject><subject>Sugar Alcohols - pharmacology</subject><subject>Sulfates - pharmacology</subject><subject>Thiosugars - pharmacology</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UcFu1DAUtBCItgs_wAFZ4sKhoXaenTgXpKqiUKkSh8LZcpznXZckXmxnEX-Pt1tK4cDF9ntvZuzxEPKKs3ecsfYscS64qljNK8ZlXVfsCTnmqill3cHTcgbBKhACjshJSreMiRqAPydHAB1jEuQxiec04s7jDxocNXP2gzc9Zm-psdnvkOaND2lZm0jTMrow-2VKpzSZ0Vg_h7FwBjpj-BZyaZXGKXUxTHRbipz2onmDdI3zkujNHcm8IM-cGRO-vN9X5Ovlhy8Xn6rrzx-vLs6vKys7nivVsd6gAlm8yIazwbWCCWelwR4VNtg76YQF0wjFrWrV0Jmeyb5tXGMtq2FF3h90t0s_4WBxztGMehv9ZOJPHYzXf09mv9HrsNOKy06JvcDbe4EYvi-Ysp58sjgWaxiWpGvJVQtdWQv0zT_Q27DEudgrKABoYP_1K1IfUDaGlCK6h8dwpveR6kOkukSq7yLVrJBeP7bxQPmdYQHAAZDKaF5j_HP3f2R_AYfArko</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Morikawa, Toshio</creator><creator>Ninomiya, Kiyofumi</creator><creator>Tanabe, Genzoh</creator><creator>Matsuda, Hisashi</creator><creator>Yoshikawa, Masayuki</creator><creator>Muraoka, Osamu</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2794-5365</orcidid></search><sort><creationdate>20210601</creationdate><title>A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia</title><author>Morikawa, Toshio ; Ninomiya, Kiyofumi ; Tanabe, Genzoh ; Matsuda, Hisashi ; Yoshikawa, Masayuki ; Muraoka, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-890bae8352935610df7404fc5aebe8e6ebf5f4c3a6481c878d9ab05b76f6cc023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antidiabetics</topic><topic>Biological products</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Dietary supplements</topic><topic>Flowers & plants</topic><topic>Functional foods & nutraceuticals</topic><topic>Humans</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Japan</topic><topic>Medicinal Chemistry</topic><topic>Medicinal plants</topic><topic>Medicine, Ayurvedic</topic><topic>Molecular Structure</topic><topic>Obesity - prevention & control</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Roots - chemistry</topic><topic>Plant Sciences</topic><topic>Plant Stems - chemistry</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review</topic><topic>Salacia</topic><topic>Salacia - chemistry</topic><topic>Sugar Alcohols - pharmacology</topic><topic>Sulfates - pharmacology</topic><topic>Thiosugars - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morikawa, Toshio</creatorcontrib><creatorcontrib>Ninomiya, Kiyofumi</creatorcontrib><creatorcontrib>Tanabe, Genzoh</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><creatorcontrib>Yoshikawa, Masayuki</creatorcontrib><creatorcontrib>Muraoka, Osamu</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morikawa, Toshio</au><au>Ninomiya, Kiyofumi</au><au>Tanabe, Genzoh</au><au>Matsuda, Hisashi</au><au>Yoshikawa, Masayuki</au><au>Muraoka, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>75</volume><issue>3</issue><spage>449</spage><epage>466</epage><pages>449-466</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (
1
) and neokotalanol (
4
), and related thiosugar sulfoniums, from the roots and stems of the genus
Salacia
plants [Celastraceae (Hippocrateaceae)] such as
Salacia reticulata
Wight,
S. oblonga
Wall., and
S. chinensis
L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus
Salacia
, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
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| fulltext | fulltext |
| identifier | ISSN: 1340-3443 |
| ispartof | Journal of natural medicines, 2021-06, Vol.75 (3), p.449-466 |
| issn | 1340-3443 1861-0293 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8159842 |
| source | Springer Nature |
| subjects | Animals Antidiabetics Biological products Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - prevention & control Dietary supplements Flowers & plants Functional foods & nutraceuticals Humans Hypoglycemic Agents - pharmacology Japan Medicinal Chemistry Medicinal plants Medicine, Ayurvedic Molecular Structure Obesity - prevention & control Pharmacology/Toxicology Pharmacy Plant Roots - chemistry Plant Sciences Plant Stems - chemistry Randomized Controlled Trials as Topic Review Salacia Salacia - chemistry Sugar Alcohols - pharmacology Sulfates - pharmacology Thiosugars - pharmacology |
| title | A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia |
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