Genetic Risk Factors in Early-Onset Nonalcoholic Chronic Pancreatitis: An Update

Chronic pancreatitis (CP) is a progressive, irreversible inflammatory disorder of the pancreas, which results from interrelations between different genetic and environmental factors. Genetic variants are the primary cause of the disease in early-onset nonalcoholic CP patients. Novel CP-associated ge...

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Bibliographic Details
Published in:Genes 2021-05, Vol.12 (5), p.785
Main Authors: Wertheim-Tysarowska, Katarzyna, Oracz, Grzegorz, Rygiel, Agnieszka Magdalena
Format: Article
Language:English
Subjects:
Adults
Age
Cystic fibrosis
Disease
Endoplasmic reticulum
Endoscopy
Environmental factors
Etiology
Genes
Genetic diversity
Genetic factors
Genetic screening
Health risk assessment
Inflammatory diseases
Pancreas
Pancreatitis
Pediatrics
Proteins
Retention
Review
Risk factors
Ultrasonic imaging
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Summary:Chronic pancreatitis (CP) is a progressive, irreversible inflammatory disorder of the pancreas, which results from interrelations between different genetic and environmental factors. Genetic variants are the primary cause of the disease in early-onset nonalcoholic CP patients. Novel CP-associated genes are continuously emerging from genetic studies on CP cohorts, providing important clues for distinct mechanisms involved in CP development. On the basis of functional studies, the genetic alterations have been sub-grouped into CP-driving pathological pathways. This review focuses on the concept of CP as a complex disease driven by multiple genetic factors. We will discuss only well-defined genetic risk factors and distinct functional pathways involved in CP development, especially in the context of the early-onset nonalcoholic CP group. The diagnostic implications of the genetic testing will be addressed as well.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12050785