Circ_0137287 suppresses cell tumroigenesis and aerobic glycolysis in papillary thyroid carcinoma through miR-183-5p/PPP2R2A axis

Circ_0137287 was found to be decreased in papillary thyroid cancer (PTC) tissues and related to aggressive clinicopathologic characteristics. However, the role and mechanism of circ_0137287 in PTC remain vague. Circ_0137287 expression was decreased in PTC and its low expression predicted poor surviv...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2021-06, Vol.73 (3), p.497-511
Main Authors: Ma, Jingjing, Kan, Zhenghua
Format: Article
Language:English
Subjects:
Acidification
Apoptosis
Biochemistry
Biomarkers
Biomedicine
Biotechnology
Cell adhesion & migration
Cell culture
Cell growth
Cell migration
Cell proliferation
Chemistry
Chemistry and Materials Science
Glucose
Glycolysis
Medical prognosis
Metabolism
Metastasis
Original
Original Article
Papillary thyroid cancer
Papillary thyroid carcinoma
Pathogenesis
Therapeutic targets
Thyroid cancer
Tumorigenesis
Tumors
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Summary:Circ_0137287 was found to be decreased in papillary thyroid cancer (PTC) tissues and related to aggressive clinicopathologic characteristics. However, the role and mechanism of circ_0137287 in PTC remain vague. Circ_0137287 expression was decreased in PTC and its low expression predicted poor survival. The ROC analysis suggested circ_0137287 might be a marker for PTC diagnosis. Circ_0137287 overexpression in PTC cells impaired cell proliferation, migration, invasion, and aerobic glycolysis, but induced apoptosis in vitro and in vivo. Circ_0137287 specifically bound to miR-183-5p, and miR-183-5p reversed the inhibitory effects of circ_0137287 on PTC tumor growth, motility and aerobic glycolysis. MiR-183-5p directly targeted PPP2R2A, and promoted PTC progression through regulating PPP2R2A. Mechanistically, circ_0137287 could indirectly modulate PPP2R2A expression through targeting miR-183-5p. Circ_0137287 suppressed PTC tumorigenesis and aerobic glycolysis through up-regulating PPP2R2A via miR-183-5p absorption, indicating a promising prognostic, diagnostic and therapeutic target.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-021-00473-4