Odontogenic fibroma amyloid-variant: a typical case and brief considerations about mimickers

The World Health Organization’s (WHO) updated classification of head and neck tumors (2017) defined odontogenic fibroma as a rare neoplasm. In this report, we describe an unusual, typical and rare variant of a central odontogenic fibroma with diffuse amyloid-like protein stromal deposition, and disc...

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Bibliographic Details
Published in:Pathologica 2021-04, Vol.113 (2), p.136-140
Main Authors: de Rezende, Gisele, Bandiera, Laura, Motta, Valentina, Bonoldi, Emanuela
Format: Article
Language:English
Subjects:
Case Report
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Summary:The World Health Organization’s (WHO) updated classification of head and neck tumors (2017) defined odontogenic fibroma as a rare neoplasm. In this report, we describe an unusual, typical and rare variant of a central odontogenic fibroma with diffuse amyloid-like protein stromal deposition, and discuss the differential diagnosis with other entities. Radiographically, this lesion presented as a well-defined radiolucency of the mandible, partially cystic. Histologically, the lesion showed a unique confluence of odontogenic epithelial rests in a moderately cellular connective tissue. Immunohistochemical staining highlighted a mixture of benign epithelial and Langerhans cells within connective tissue with diffuse amyloid-like stromal deposition. The importance of recognizing this variant of odontogenic fibroma is due to its benign prognosis and clinical course.
ISSN:1591-951X
0031-2983
1591-951X
DOI:10.32074/1591-951X-152