Factors predicting long-term changes in refraction after lamellar keratoscleroplasty in children with limbal dermoids

• Published in: Eye (London) 2021-06, Vol.35 (6), p.1659-1665
• Main Authors: Fan, Xiangyu, Hong, Jiaxu, Xiang, Jun, Cheng, Jingyi, Xu, Jianjiang
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/699/3161/3163; Astigmatism; Children; Cornea; Graft rejection; Laboratory Medicine; Lesions; Medicine; Medicine & Public Health; Ophthalmology; Patients; Pharmaceutical Sciences/Technology; Refraction; Surgery; Surgical Oncology; Sutures
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/s41433-020-01140-2

Objectives The objective of this study is to determine the factors that predict long-term changes in refraction after lamellar keratoscleroplasty in paediatric patients with limbal dermoids. Methods A retrospective study of 66 children with limbal dermoids who had lamellar keratoscleroplasty correction with more than 1-year follow-up. Univariate and multivariate regression analyses were performed to investigate factors associated with the long term in refractive parameters, including spherical equivalent, astigmatism, and mean keratometry. The change value was defined as the postoperative refractive value minus the preoperative refractive value. The lower the value of changes, the more satisfied the effects on the correction of the preoperative refraction. Results A total of 66 patients (mean surgical age: 3.5 ± 2.1 years) were assessed with at least 1-year follow-up. Amblyopia treatment duration was the only independent factor predicting the long-term changes in spherical equivalent between baseline and last follow-up visit ( β  = −0.030, P