Evaluation of subcarinal lymph node dissection and metastasis in transmediastinal radical esophagectomy

• Published in: Esophagus : official journal of the Japan Esophageal Society 2021-07, Vol.18 (3), p.461-467
• Main Authors: Shibamoto, Jun, Fujiwara, Hitoshi, Konishi, Hirotaka, Shiozaki, Atsushi, Ohashi, Takuma, Kubota, Takeshi, Shimizu, Hiroki, Arita, Tomohiro, Yamamoto, Yusuke, Morimura, Ryo, Kuriu, Yoshiaki, Ikoma, Hisashi, Okamoto, Kazuma, Otsuji, Eigo
• Format: Article
• Language: English
• Subjects: Dissection; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophagectomy; Esophagus; Gastroenterology; Gastrointestinal surgery; Humans; Lymph Node Excision; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic system; Medicine; Medicine & Public Health; Metastasis; Original; Original Article; Retrospective Studies; Surgical Oncology; Thoracic Surgery
• ISSN: 1612-9059; 1612-9067
• DOI: 10.1007/s10388-021-00824-2

Background The aim of the present study was to evaluate subcarinal lymph node dissection in transmediastinal radical esophagectomy and subcarinal lymph node metastasis in patients with esophageal cancer. Methods Three hundred and twenty-three patients with primary esophageal cancer who underwent transmediastinal or transthoracic esophagectomy with radical two- or three-field lymph node dissection were retrospectively investigated. The clinicopathological characteristics of patients with subcarinal lymph node metastasis were analyzed in detail. Results The median of dissected subcarinal lymph nodes in transmediastinal and transthoracic esophagectomy groups was 6 and 7, respectively, and there was no significant difference between the two groups ( p  = 0.12). Of all patients, 26 (8.0%) were pathologically diagnosed as positive for subcarinal lymph node metastasis, whereas only 7 (26.9%) of those with metastasis were preoperatively diagnosed as positive. In addition, all patients with subcarinal lymph node metastasis had other non-subcarinal lymph node metastasis. By univariate analysis, subcarinal lymph node metastasis was found in larger (≥ 30 mm) and deeper (T3/T4a) primary lesions ( p  = 0.02 and 0.02, respectively), but it was not found in 49 patients with the primary lesion located in the upper thoracic esophagus. Conclusions Subcarinal lymph nodes can be dissected in transmediastinal esophagectomy, almost equivalent to transthoracic esophagectomy. The tumor size, depth, and location may be predictive factors for subcarinal lymph node metastasis.