6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents

The 6-shogaol, is a flavanone type flavonoid that is abundant in citrus fruit and has a wide range of pharmacological effects. The present study attempted to evaluate the antiurolithic effect of 6-shogaol on ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. T...

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Published in:Saudi journal of biological sciences 2021-06, Vol.28 (6), p.3418-3423
Main Authors: Afzal, Muhammad, Kazmi, Imran, Quazi, Anwarulabedin Mohsin, Ahmad, Aftab, Al-Abaasi, Fahad A., Imam, Faisal, Alharbi, Khalid Saad, Alzarea, Sami I., Zafar, Ameeduzzafar
Format: Article
Language:English
Subjects:
6-Shogaol
Calcium oxalate
Ethylene glycol
Original
Urolithiasis
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Summary:The 6-shogaol, is a flavanone type flavonoid that is abundant in citrus fruit and has a wide range of pharmacological effects. The present study attempted to evaluate the antiurolithic effect of 6-shogaol on ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. The efficacy of 6-shogaol 50 mg/kg and 100 mg/kg was studied in EG 0.75% (V/V) and AC 1% (W/V) experimentally induced urolithiasis in rats for 21 days. The weight difference, urine volume, the levels of calcium, phosphate, magnesium, oxalate and uric acid in urine was observed. The blood urea nitrogen, creatinine, uric acid in serum and levels of malondialdehyde (MDA) and glutathione (GSH) were also measured. Histopathological analyses in kidneys were also performed. The rats weights were higher in the 6-shogaol groups than the urolithiasis group. EG caused a significant increase in serum creatinine (p 
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2021.03.005