Balancing risk in a patient with primary bone histiocytic sarcoma during pregnancy: Case report and review of the literature

• Published in: International journal of surgery case reports 2021-06, Vol.83, p.106021-106021, Article 106021
• Main Authors: Al-Amri, Ayman, Al-Khabori, Murtadha, Al-Riyami, Nihal, Al-Haddabi, Ibrahim
• Format: Article
• Language: English
• Subjects: Case Report; Histiocytic sarcoma; Pregnancy; Proximal humerus
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2021.106021

Histiocytic sarcoma (HS) is a rare, aggressive malignant neoplasm of hematopoietic cell origin. Primary HS of the proximal humerus, without involvement of lymph nodes or bone marrow, or systemic features, is very rare. We report a rare case of primary bony HS of the proximal humerus without bone marrow involvement in a healthy 33-year-old pregnant woman. She was successfully treated with surgical resection during pregnancy and radiotherapy post-delivery. This is the first report of a patient with primary bony HS during pregnancy. This highlights the fact that although HS is a neoplasm of hemolymphoid cell lineage, it frequently arises in non-lymphoid organs. This case emphasizes the importance of a multidisciplinary approach and the need for balancing treatment risk in a patient with primary bone HS during pregnancy. •Histiocytic sarcoma is a rare aggressive malignant neoplasm of hematopoietic cell origin.•Primary bony histiocytic sarcoma during pregnancy is extremely rare and difficult to diagnose.•Treatment is challenging in a patient with histiocytic sarcoma during pregnancy.