Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of Heliotropium indicum L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDire...

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Published in:Evidence-based complementary and alternative medicine 2021-06, Vol.2021, p.1-21
Main Authors: Sarkar, Chandan, Mondal, Milon, Khanom, Bilkis, Hossain, Md. Monir, Hossain, Md. Solayman, Sureda, Antoni, Islam, Muhammad Torequl, Martorell, Miquel, Kumar, Manoj, Sharifi-Rad, Javad, Al-Harrasi, Ahmed, Al-Rawahi, Ahmed
Format: Article
Language:English
Subjects:
Alternative medicine
Amines
Animal models
Anthelmintic agents
Antioxidants
Antiprotozoal agents
Bioactive compounds
Chicken pox
Diuretics
Drug dosages
Ethnomedicine
Flowers & plants
Heliotropium indicum
Herbal medicine
Infections
Larvicides
Menstruation
Morphology
Natural products
Pain
Pain perception
Phytochemicals
Poisoning
Pyrrolizidine alkaloids
Review
Sterols
Toxicity
Triterpenes
Tropical diseases
Wound healing
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Summary:This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of Heliotropium indicum L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDirect, ResearchGate, PubMed, Chem Spider, Elsevier, BioMed Central, and patent offices (e.g., USPTO, CIPO, NPI, Google patents, and Espacenet) for the published materials. The findings suggest that the plant contains many important phytochemicals, including pyrrolizidine alkaloids, indicine, echinitine, supinine, heleurine, heliotrine, lasiocarpine, acetyl indicine, indicinine, indicine N-oxide, cynoglossine, europine N-oxide, heleurine N-oxide, heliotridine N-oxide, heliotrine N-oxide, heliotrine, volatile oils, triterpenes, amines, and sterols. Scientific reports revealed that the herb showed antioxidant, analgesic, antimicrobial, anticancer, antituberculosis, antiplasmodial, anticataract, antifertility, wound healing, antiinflammatory, antinociceptive, antihyperglycemic, anthelmintic, diuretic, antitussive, antiglaucoma, antiallergic, and larvicidal activity. In conclusion, in vitro studies with animal models seem to show the potential beneficial effects of H. indicum against a wide variety of disorders and as a source of phytotherapeutic compounds. However, clinical studies are necessary to confirm the effects observed in animal models, determine the toxicity of the therapeutic dose and isolate the truly bioactive components.
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/9965481