Gastrointestinal Motility and Gut Hormone Secretion in response to Shenhuang Plaster in a Postoperative Ileus Rat Model

Postoperative ileus (POI), a gastrointestinal function disorder, is a complication that arises from surgery. Shenhuang plaster (SHP) application to the Shenque acupoint (CV8) to promote the recovery of gastrointestinal function has achieved definite curative effects in clinical settings; however, th...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2021, Vol.2021, p.1-10
Main Authors: Shi, Yanan, Zheng, Yingsong, Xu, Jingming, Ding, Bin, Shou, Qiyang, Chen, Guiping, Liu, Ting, Sun, Qiuhua, Xu, Xiaohong
Format: Article
Language:English
Subjects:
Abdomen
Acupuncture
Alternative medicine
Animal models
Antibodies
Blood levels
Chinese medicine
Dextran
Experiments
Fluorescein
Gastric motility
Ghrelin
Hormones
Intestine
Laboratory animals
Medical research
Motility
Radioimmunoassay
Small intestine
Surgery
Vasoactive agents
Vasoactive intestinal peptide
Western blotting
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Summary:Postoperative ileus (POI), a gastrointestinal function disorder, is a complication that arises from surgery. Shenhuang plaster (SHP) application to the Shenque acupoint (CV8) to promote the recovery of gastrointestinal function has achieved definite curative effects in clinical settings; however, the underlying pharmacological mechanism remains unknown. In this study, we evaluated the effects of SHP using a Sprague Dawley rat POI model. Then, gastrointestinal transit in different rat groups was evaluated by the movement of fluorescein-labelled dextran. Ghrelin, obestatin, motilin (MTL), and vasoactive intestinal peptide (VIP) plasma concentrations were measured via a radioimmunoassay. The expression of the ghrelin and obestatin receptors (GHS-R1α and GPR39) in the intestinal muscularis of rats in different groups was comparatively identified via western blotting. The results indicated that SHP application improved gastrointestinal motility in POI model rats. SHP application significantly increased ghrelin concentration and the expression of its receptor and inhibited obestatin concentration and the expression of its receptor in blood. Further, ghrelin concentration and the capability of gastrointestinal transit were positively correlated. Simultaneously, SHP application also promoted the secretion of other gastrointestinal motility hormones, such as MTL and VIP. Hence, these results provide evidence that SHP can promote the recovery of gastrointestinal transmission in POI rat models through regulation of ghrelin and other intestinal hormones.
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/8859579