Dual-energy CT collagen density mapping of wrist ligaments reveals tissue remodeling in CPPD patients: first results from a clinical cohort

Objectives To evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group in order to gain insight into changes of the extracellular matrix in res...

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Bibliographic Details
Published in:Skeletal radiology 2021-02, Vol.50 (2), p.417-423
Main Authors: Ziegeler, Katharina, Richter, Sophia-Theresa, Hermann, Sandra, Hermann, Kay Geert A., Hamm, Bernd, Diekhoff, Torsten
Format: Article
Language:English
Subjects:
Calcification
Calcium
Calcium phosphate
Cohort analysis
Collagen
Computed tomography
Density
Deposition
Diagnostic imaging
Disease control
Extracellular matrix
Imaging
Ligaments
Medicine
Medicine & Public Health
Nuclear Medicine
Orthopedics
Pathology
Radiology
Regression analysis
Scientific
Scientific Article
Specific gravity
Wrist
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Summary:Objectives To evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group in order to gain insight into changes of the extracellular matrix in response to crystal deposition. Materials and methods This retrospective study included 28 patients (18 with CPPD, 10 controls) who underwent DECT of the wrist. Collagen density maps were reconstructed from the DECT datasets and used to measure densities in regions of interest (ROIs) placed in the scapholunate (SL) ligament (dorsal, palmar, proximal), lunotriquetral (LT) ligament, and extensor carpi radialis (ECR) tendon, ( n  = 260 measurements). The presence of calcifications on standard CT images in these regions was assessed by a blinded reader. Densities were compared with nonparametric tests, and linear regression analysis was performed to investigate the impact of age, sex, and CT- detected calcium deposition on collagen density. Results Collagen density in the SL ligament was significantly higher in CPPD patients than in controls (overall mean: 265.4 ± 32.1 HU vs. 196.3 ± 33.8 HU; p  
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-020-03580-z