Reproductive outcomes after preimplantation genetic testing in mosaic Turner syndrome: a retrospective cohort study of 100 cycles

Purpose The purpose of this study is to explore the reproductive outcomes of women with Turner syndrome (TS) in preimplantation genetic testing (PGT) cycles. Methods A retrospective study of 100 controlled ovarian stimulating cycles, 68 TS (sixty-four mosaic Turner syndrome (MTS) and four pure Turne...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2021-05, Vol.38 (5), p.1247-1253
Main Authors: Liao, Jingnan, Luo, Keli, Cheng, Dehua, Xie, Pingyuan, Tan, Yueqiu, Hu, Liang, Lu, Guangxiu, Gong, Fei, Lin, Ge
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - genetics
Abortion, Spontaneous - pathology
Adult
Aneuploidy
Birth Rate
Blastocyst - metabolism
Chromosome aberrations
Cohort analysis
Embryo Transfer - methods
Female
Fertilization in Vitro - trends
Genetic disorders
Genetic screening
Genetic Testing - trends
Genetics
Gynecology
Human Genetics
Humans
Karyotypes
Live Birth - epidemiology
Live Birth - genetics
Medicine
Medicine & Public Health
Mosaicism
Pregnancy
Pregnancy Rate
Preimplantation Diagnosis
Reproductive Medicine
Turner Syndrome - diagnosis
Turner Syndrome - genetics
Turner Syndrome - pathology
Turner's syndrome
X chromosomes
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Summary:Purpose The purpose of this study is to explore the reproductive outcomes of women with Turner syndrome (TS) in preimplantation genetic testing (PGT) cycles. Methods A retrospective study of 100 controlled ovarian stimulating cycles, 68 TS (sixty-four mosaic Turner syndrome (MTS) and four pure Turner syndrome (PTS)) women underwent PGT was conducted from 2013 to 2018. Results Embryo X chromosome abnormal rates of TS women were significantly higher than women with normal karyotype (7.04 vs 1.61%, P
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-021-02127-y