The relationship between intermittent hypoxemia events and neural outcomes in neonates

This brief review examines 1) patterns of intermittent hypoxemia in extremely preterm infants during early postnatal life, 2) the relationship between neonatal intermittent hypoxemia exposure and outcomes in both human and animal models, 3) potential mechanistic pathways, and 4) future alterations i...

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Bibliographic Details
Published in:Experimental neurology 2021-08, Vol.342, p.113753-113753, Article 113753
Main Authors: Di Fiore, Juliann M., Raffay, Thomas M.
Format: Article
Language:English
Subjects:
Hypoxia
Inflammation
Intermittent hypoxemia
Neurodevelopmental impairment
Neurotransmitters
Oxidative stress
Retinopathy of prematurity
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Summary:This brief review examines 1) patterns of intermittent hypoxemia in extremely preterm infants during early postnatal life, 2) the relationship between neonatal intermittent hypoxemia exposure and outcomes in both human and animal models, 3) potential mechanistic pathways, and 4) future alterations in clinical care that may reduce morbidity. Intermittent hypoxemia events are pervasive in extremely preterm infants (
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2021.113753