Relation Between Body Composition, Systemic Inflammatory Response, and Clinical Outcomes in Patients Admitted to an Urban Teaching Hospital with COVID-19

COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clini...

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Published in:The Journal of Nutrition 2021-08, Vol.151 (8), p.2236-2244
Main Authors: McGovern, Josh, Dolan, Ross, Richards, Conor, Laird, Barry J, McMillan, Donald C, Maguire, Donogh
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Body Composition
Body Mass Index
Clinical outcomes
Computed tomography
COVID-19
COVID-19 - metabolism
COVID-19 - mortality
COVID-19 - pathology
Demographic variables
Female
Hospitalization
Hospitals, Teaching
Humans
Inflammation
Inflammation - etiology
Inflammatory response
Intensive care
Intra-Abdominal Fat
Male
Middle Aged
Mortality
Nutrition
Nutrition and Disease
Obesity
Patients
Sarcopenia
Sarcopenia - etiology
SARS-CoV-2
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description COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19. Patients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR, CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted. Sixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P < 0.05). Thirty-day mortality was associated with high VFA (P < 0.05) and low SMI (P < 0.05). Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.
doi_str_mv 10.1093/jn/nxab142
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subjects Adult
Aged
Aged, 80 and over
Body Composition
Body Mass Index
Clinical outcomes
Computed tomography
COVID-19
COVID-19 - metabolism
COVID-19 - mortality
COVID-19 - pathology
Demographic variables
Female
Hospitalization
Hospitals, Teaching
Humans
Inflammation
Inflammation - etiology
Inflammatory response
Intensive care
Intra-Abdominal Fat
Male
Middle Aged
Mortality
Nutrition
Nutrition and Disease
Obesity
Patients
Sarcopenia
Sarcopenia - etiology
SARS-CoV-2
title Relation Between Body Composition, Systemic Inflammatory Response, and Clinical Outcomes in Patients Admitted to an Urban Teaching Hospital with COVID-19
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