Prospective observational trial of low-dose skin electron beam therapy in mycosis fungoides using a rotational technique

• Published in: Journal of the American Academy of Dermatology 2021-07, Vol.85 (1), p.121-127
• Main Authors: Newman, Neil B., Patel, Chirayu G., Ding, George X., Zic, John A., Zwerner, Jeffrey, Osmundson, Evan C., Kirschner, Austin N.
• Format: Article
• Language: English
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2020.12.023

Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique and dosing regimen. Patients completed baseline Skindex-29 quality-of-life surveys and had baseline Modified Severity-Weighted Assessment Tool score recorded. Patients received 12 Gy in 12 fractions with a dual-field rotational technique. The primary outcome was overall response rate, with the secondary outcomes being time to treatment response, duration of clinical benefit, and quality-of-life change. We enrolled 20 patients and recorded an overall response rate of 90%. The median time to treatment response was 6.5 weeks. The baseline Modified Severity-Weighted Assessment Tool score was 55.6 and it declined to a median of 2.2 at last follow-up (P