Giant Cell Tumor of Bone in Patients under 16 Years Old: A Single-Institution Case Series

Background: Giant cell tumor of bone is a locally aggressive, rarely metastasizing tumor that accounts for about 5% of bone tumors and generally occurs in patients between 20 and 45 years old. A driver mutation in the histone 3.3 (H3.3) gene H3F3A has been identified in as many as 96% of giant cell...

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Bibliographic Details
Published in:Cancers 2021-05, Vol.13 (11), p.2585
Main Authors: Ambrosi, Francesca, Righi, Alberto, Benini, Stefania, Magagnoli, Giovanna, Chiaramonte, Ilaria, Manfrini, Marco, Gasbarrini, Alessandro, Frisoni, Tommaso, Gambarotti, Marco
Format: Article
Language:English
Subjects:
Aneurysm
Bone tumors
Bones
Cloning
Cysts
Differential diagnosis
Histones
Immunohistochemistry
Mutation
Orthopedics
Patients
Pediatrics
Point mutation
Proteins
Tumors
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Summary:Background: Giant cell tumor of bone is a locally aggressive, rarely metastasizing tumor that accounts for about 5% of bone tumors and generally occurs in patients between 20 and 45 years old. A driver mutation in the histone 3.3 (H3.3) gene H3F3A has been identified in as many as 96% of giant cell tumors of bone. The immunohistochemical expression of H3F3A H3.3 G34 expression was found in 97.8% of cases. In the present study, we describe our series of cases of giant cell tumor of bone in pediatric patients
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13112585