Association between Skin Cancer and Systemic and Ocular Comorbidities in South Korea

Background: In this study, we investigated the associations between various systemic and ocular comorbidities and skin cancer, in a nationwide cohort of South Koreans. Method: We reviewed the data of 1,103,302 individuals in the South Korean National Health Insurance Service-National Sample Cohort d...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-06, Vol.10 (11), p.2451
Main Authors: Lee, Sul Hee, Ro, Jun-Soo, Chung, Kee Yang, Lee, Sang Hoon, Park, Young Lip, Kim, Jung Eun, Lee, Si Hyung
Format: Article
Language:English
Subjects:
Age groups
Cardiovascular disease
Cataracts
Chronic obstructive pulmonary disease
Clinical medicine
Comorbidity
Coronary vessels
Health care access
Heart attacks
Hypertension
Investigations
Macular degeneration
Melanoma
Neighborhoods
Parkinson's disease
Population
Regression analysis
Skin cancer
Trends
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Summary:Background: In this study, we investigated the associations between various systemic and ocular comorbidities and skin cancer, in a nationwide cohort of South Koreans. Method: We reviewed the data of 1,103,302 individuals in the South Korean National Health Insurance Service-National Sample Cohort database from 2002 to 2015. Of these, 1202 individuals diagnosed with skin cancer from 2004 were included in the study group. The control group was matched in a 1:5 ratio based on propensity scores. Results: The prevalence rates of melanoma and non-melanoma skin cancer increased from 2004 to 2015. Multivariate logistic regression analysis revealed that, among the various systemic conditions, hypertension was significantly associated with skin cancer, while among ocular comorbidities, macular degeneration showed a significant association with skin cancer. Conclusions: This is the first study to demonstrate associations between skin cancer and various systemic and ocular comorbidities. The results suggest that hypertension and macular degeneration may increase the risk of skin cancer development, or vice versa. Further studies are needed to evaluate the causal relationships between these conditions.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10112451