Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylph...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-05, Vol.18 (11), p.5929
Main Authors: Nishihama, Yukiko, Nakayama, Shoji, Isobe, Tomohiko, Jung, Chau-Ren, Iwai-Shimada, Miyuki, Kobayashi, Yayoi, Michikawa, Takehiro, Sekiyama, Makiko, Taniguchi, Yu, Yamazaki, Shin
Format: Article
Language:English
Subjects:
Biomarkers
Body mass
Body mass index
Body size
Calibration
Children
Confidence limits
Control charts
Creatinine
Fenitrothion
Laboratories
Learning algorithms
Metabolites
Organophosphates
Organophosphorus pesticides
Pesticide toxicity
Pesticides
Potassium
Pregnancy
Prenatal experience
Prenatal exposure
Risk assessment
Toxicity
Urine
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Summary:Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18115929