Rosacea: New Concepts in Classification and Treatment

Rosacea is a chronic inflammatory dermatosis mainly affecting the cheeks, nose, chin, and forehead. Rosacea is characterized by recurrent episodes of flushing or transient erythema, persistent erythema, phymatous changes, papules, pustules, and telangiectasia. The eyes may also be involved. Due to r...

Full description

Saved in:
Bibliographic Details
Published in:American journal of clinical dermatology 2021-07, Vol.22 (4), p.457-465
Main Authors: van Zuuren, Esther J., Arents, Bernd W. M., van der Linden, Mireille M. D., Vermeulen, Sofieke, Fedorowicz, Zbys, Tan, Jerry
Format: Article
Language:English
Subjects:
Chemokines
Classification
Cytokines
Dermatology
Erythema
Genotype & phenotype
Inflammation
Leading
Leading Article
Medicine
Medicine & Public Health
Pathophysiology
Patients
Peptides
Pharmacology/Toxicology
Pharmacotherapy
Quality of life
Rosacea
Self esteem
Skin care
Well being
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rosacea is a chronic inflammatory dermatosis mainly affecting the cheeks, nose, chin, and forehead. Rosacea is characterized by recurrent episodes of flushing or transient erythema, persistent erythema, phymatous changes, papules, pustules, and telangiectasia. The eyes may also be involved. Due to rosacea affecting the face, it has a profound negative impact on quality of life, self-esteem, and well-being. In addition to general skin care, there are several approved treatment options available for addressing these features, both topical and systemic. For some features, intense pulse light, laser, and surgery are of value. Recent advances in fundamental scientific research have underscored the roles of the innate and adaptive immune systems as well as neurovascular dysregulation underlying the spectrum of clinical features of rosacea. Endogenous and exogenous stimuli may initiate and aggravate several pathways in patients with rosacea. This review covers the new phenotype-based diagnosis and classification system reflecting pathophysiology, and new and emerging treatment options and approaches. We address new topical and systemic formulations, as well as recent evidence on treatment combinations. In addition, ongoing studies investigating novel therapeutic interventions will be summarized.
ISSN:1175-0561
1179-1888
DOI:10.1007/s40257-021-00595-7