Contribution of serum anti-Müllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men

Testicular sperm extraction (TESE) is the method of choice for recovering spermatozoa in patients with azoospermia. However, the lack of reliable biomarkers makes it impossible to predict sperm retrieval outcomes at TESE. To date, little attention has been given to anti-Müllerian hormone (AMH) serum...

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Bibliographic Details
Published in:Basic and clinical andrology 2021-06, Vol.31 (1), p.15, Article 15
Main Authors: Benderradji, Hamza, Prasivoravong, Julie, Marcelli, François, Barbotin, Anne-Laure, Catteau-Jonard, Sophie, Marchetti, Carole, Guittard, Catherine, Puech, Philippe, Mitchell, Valérie, Rigot, Jean-Marc, Villers, Arnauld, Pigny, Pascal, Leroy, Clara
Format: Article
Language:English
Subjects:
Chemotherapy
Cryptorchidism
Etiology
Laboratories
Patients
Radiation therapy
Sperm
Spermatogenesis
Surgery
Testes
Testosterone
Tumors
Ultrasonic imaging
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Summary:Testicular sperm extraction (TESE) is the method of choice for recovering spermatozoa in patients with azoospermia. However, the lack of reliable biomarkers makes it impossible to predict sperm retrieval outcomes at TESE. To date, little attention has been given to anti-Müllerian hormone (AMH) serum levels in adult men with altered spermatogenesis. In this study we aimed to investigate whether serum concentrations of AMH and the AMH to total testosterone ratio (AMH/T) might be predictive factors for sperm retrieval outcomes during TESE in a cohort of 155 adult Caucasian men with azoospermia. AMH serum levels were significantly lower in nonobstructive azoospermia (NOA) that was unexplained, cryptorchidism-related, cytotoxic and genetic (medians [pmol/l] = 30.1; 21.8; 26.7; 7.3; and p = 0.02; 0.001; 0.04;
ISSN:2051-4190
2051-4190
DOI:10.1186/s12610-021-00133-9