Assessment of fecal Akkermansia muciniphila in patients with osteoporosis and osteopenia: a pilot study

Objectives Osteoporosis is characterized by slow deterioration in bone mass and disruption of its structure, leading to an increased risk of bone fractures. Gut microbiota plays an important role in the transport and absorption of nutrients needed for bone health. Akkermansia muciniphila is one of t...

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Published in:Journal of diabetes and metabolic disorders 2021-06, Vol.20 (1), p.279-284
Main Authors: Keshavarz Azizi Raftar, Shahrbanoo, Hoseini Tavassol, Zahra, Amiri, Meysam, Ejtahed, Hanieh-Sadat, Zangeneh, Mehrangiz, Sadeghi, Sedigheh, Ashrafian, Fatemeh, Kariman, Arian, Khatami, Shohreh, Siadat, Seyed Davar
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Cross-talk between gut microbiota and the endocrine system
Diabetes
Endocrinology
Genomics
Medicine
Medicine & Public Health
Menopause
Metabolic Diseases
Microbiota (Symbiotic organisms)
Osteoporosis
Postmenopausal women
Prevention
Research Article
RNA
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Summary:Objectives Osteoporosis is characterized by slow deterioration in bone mass and disruption of its structure, leading to an increased risk of bone fractures. Gut microbiota plays an important role in the transport and absorption of nutrients needed for bone health. Akkermansia muciniphila is one of the gut microbiota members that its beneficial role in prevention of metabolic disorder was suggested. The aim of the current pilot study was the assessment of fecal A. muciniphila in patients with osteoporosis and osteopenia. Methods A total of 36 subjects including eight with osteoporosis (three men and five women), eight with osteopenia (two men and six women), and 20 normal controls (six men and 14 women) were selected. Microbial genome was extracted from fresh stool samples. The bacterial load was determined by quantitative real-time PCR using 16S rRNA specific primers. Results The participants’ mean age in the osteoporosis, osteopenia and control groups were 61.71, 45 and 45.05 years, respectively. The majority of osteoporosis patients were post-menopause women, while in osteopenia group was pre-menopause. There were significant differences in terms of age, T-score, Z-score, and menopause among groups ( P value  
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-021-00742-1