Determining the association between hypertension and bone metabolism markers in osteoporotic patients

• Published in: Medicine (Baltimore) 2021-06, Vol.100 (24), p.e26276-e26276
• Main Authors: Hu, Zhuoqing, Yang, Kevin, Hu, Zhihui, Li, Miaosheng, Wei, Hao, Tang, Zheng, Chen, Baitong, Su, Chengbiao, Cai, De, Xu, Jinrong
• Format: Article
• Language: English
• Subjects: Aged; Alkaline Phosphatase - blood; Biomarkers - blood; Bone Remodeling; Cross-Sectional Studies; Female; Humans; Hypertension - blood; Hypertension - complications; Male; Middle Aged; Multivariate Analysis; Observational Study; Osteocalcin - blood; Osteoporosis - blood; Osteoporosis - complications; Risk Factors; Sex Factors; Tartrate-Resistant Acid Phosphatase - blood; Vitamin D - analogs & derivatives; Vitamin D - blood
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000026276

The aim of the case study is to examine the association between hypertension and the level of bone metabolism markers in newly diagnosed osteoporotic patients.A cross-sectional study of 518 subjects was done to see the association between hypertension and the level of osteocalcin (OC), bone-specific alkaline phosphatase (B-ALP), Tartrate-resistant acid phosphatase (TRAP.5B), and 25-hydroxy vitamin D (25-OHD). There were 243 (46.9%) osteoporosis patients with hypertension. Both univariate and multivariate analysis have suggested that lower OC and 25-OHD levels were associated with hypertension. The potential confounders-adjusted OC level was significantly lower in hypertensive female group than that in the female without hypertension group [β = -0.20, 95% confidence interval (95% CI) = -0.37 to -0.03, P = .02 in final adjust model]. The potential confounders-adjusted 25-OHD level was significantly lower in hypertensive male group than that in male without hypertension group (β = -0.34, 95% CI = -0.58 to -0.10, P = .01 in final adjust model). The B-ALP and TRACP.5B levels were positively associated with hypertension in all patients or subgroup analysis. However, all the correlations had no statistical significance for the B-ALP and TRACP.5B.In conclusion, the hypertension was associated with low level of OC and 25-OHD. Hypertension probably led to low bone turnover, which may be one of the mechanisms of hypertension-related osteoporosis.