Genomic subtypes may predict the risk of central nervous system recurrence in diffuse large B-cell lymphoma

Ollila et al address a challenging problem: can the risk for central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma be predicted better on a molecular basis? They report that most tumors with CNS recurrence have recognizable molecular features that fall into two categori...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2021-02, Vol.137 (8), p.1120-1124
Main Authors: Ollila, Thomas A., Kurt, Habibe, Waroich, Jozal, Vatkevich, John, Sturtevant, Ashlee, Patel, Nimesh R., Dubielecka, Patrycja M., Treaba, Diana O., Olszewski, Adam J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Central Nervous System Neoplasms - genetics
Central Nervous System Neoplasms - pathology
Female
Gene Rearrangement
Humans
Letter to
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Middle Aged
Mutation
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ollila et al address a challenging problem: can the risk for central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma be predicted better on a molecular basis? They report that most tumors with CNS recurrence have recognizable molecular features that fall into two categories: those that resemble primary CNS lymphoma and those that resemble high-grade lymphoma. These data suggest that it is time to revisit identification of patients who may benefit from CNS prophylaxis, while highlighting how challenging that is.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2020007236