Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants

Background and purpose To determine whether neurofilament light chain (NfL), a promising serum and cerebrospinal fluid (CSF) biomarker of neuroaxonal damage, predicts functional outcome in preterm infants with neonatal brain injury. Methods Our prospective observational study used a sensitive single...

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Bibliographic Details
Published in:Journal of neurology 2021-07, Vol.268 (7), p.2570-2577
Main Authors: Goeral, Katharina, Hauck, Annalisa, Atkinson, Andrew, Wagner, Michael B., Pimpel, Birgit, Fuiko, Renate, Klebermass-Schrehof, Katrin, Leppert, David, Kuhle, Jens, Berger, Angelika, Olischar, Monika, Wellmann, Sven
Format: Article
Language:English
Subjects:
Adolescent
Age
Biomarkers
Brain injury
Cerebral infarction
Cerebrospinal fluid
Cognitive ability
Diagnosis
Gestation
Hemorrhage
Humans
Hydrocephalus
Infant, Newborn
Infant, Premature
Infants
Intermediate Filaments
Medicine
Medicine & Public Health
Neonates
Neurofilament Proteins
Neurology
Neuroradiology
Neurosciences
Newborn babies
Original Communication
Premature babies
Prospective Studies
Regression analysis
Risk factors
Ventricle
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Summary:Background and purpose To determine whether neurofilament light chain (NfL), a promising serum and cerebrospinal fluid (CSF) biomarker of neuroaxonal damage, predicts functional outcome in preterm infants with neonatal brain injury. Methods Our prospective observational study used a sensitive single-molecule array assay to measure serum and CSF NfL concentrations in preterm infants with moderate to severe peri/intraventricular hemorrhage (PIVH). We determined temporal serum and CSF NfL profiles from the initial diagnosis of PIVH until term-equivalent age and their association with clinical and neurodevelopmental outcome until 2 years of age assessed by Bayley Scales of Infant Development (3rd edition). We fitted univariate and multivariate logistic regression models to determine risk factors for poor motor and cognitive development. Results The study included 48 infants born at 
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-021-10429-5