Double VEGF/HGF Gene Therapy in Critical Limb Ischemia Complicated by Diabetes Mellitus

Critical leg ischemia (CLI) complicated by diabetes mellitus (DM), which is a very common and dangerous disease, represents the ultimate stage of peripheral arterial disease. Patients are treated with antiplatelet drugs, statins and limb revascularization, but a significant number of patients are no...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2021-06, Vol.14 (3), p.409-415
Main Authors: Barć, Piotr, Antkiewicz, Maciej, Śliwa, Barbara, Frączkowska, Katarzyna, Guziński, Maciej, Dawiskiba, Tomasz, Małodobra-Mazur, Małgorzata, Witkiewicz, Wojciech, Kupczyńska, Diana, Strzelec, Bartłomiej, Janczak, Dariusz, Skóra, Jan Paweł
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
Biomedical Engineering and Bioengineering
Biomedicine
Blood Glucose - metabolism
Cardiology
Critical Illness
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - therapy
Female
Functional Status
Genetic Therapy
Hepatocyte Growth Factor - genetics
Human Genetics
Humans
Internal Ribosome Entry Sites - genetics
Ischemia - blood
Ischemia - genetics
Ischemia - physiopathology
Ischemia - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Neovascularization, Physiologic
Original
Original Article
Peripheral Arterial Disease - blood
Peripheral Arterial Disease - genetics
Peripheral Arterial Disease - physiopathology
Peripheral Arterial Disease - therapy
Plasmids - genetics
Poland
Recovery of Function
Time Factors
Treatment Outcome
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - genetics
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Summary:Critical leg ischemia (CLI) complicated by diabetes mellitus (DM), which is a very common and dangerous disease, represents the ultimate stage of peripheral arterial disease. Patients are treated with antiplatelet drugs, statins and limb revascularization, but a significant number of patients are not candidate for revascularization. Literature shows that in such cases, gene therapy could be a perfect therapeutic option. The aim of our study was to evaluate efficacy of double vascular endothelial growth factor/hepatocyte growth factor (VEGF/HGF) gene therapy in patients with CLI complicated by DM. We observed that 90 days after administration, serum level of VEGF and ankle-brachial index increased significantly ( p  
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-020-10066-9