Transient left ventricular clot in COVID-19-related myocarditis is associated with hypereosinophilic syndrome: a case report

Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinoph...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2021-11, Vol.37 (11), p.3279-3283
Main Authors: Ziaie, Naghmeh, Maleh, Parviz Amri, Ramandi, Mohammad Mostafa Ansari, Pourkia, Roghayeh, Latifi, Kayvan, Mansouri, Davood
Format: Article
Language:English
Subjects:
Bone marrow
Cardiac Imaging
Cardiology
Case reports
Case-in-Point
Coronaviruses
COVID-19
Echocardiography
Eosinophilia
Fluorescence
Fluorescence in situ hybridization
Heart
Heart diseases
Humans
Hypereosinophilic Syndrome - complications
Hypereosinophilic Syndrome - diagnostic imaging
Hypereosinophilic Syndrome - drug therapy
Imaging
In Situ Hybridization, Fluorescence
Leukocytes (eosinophilic)
Medicine
Medicine & Public Health
Myocarditis
Myocarditis - diagnostic imaging
Myocarditis - etiology
Oncogene Proteins, Fusion - genetics
Patients
Predictive Value of Tests
Radiology
Rare diseases
SARS-CoV-2
Ventricle
Viral diseases
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Description
Summary:Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinophilia and organ involvement. Here, we report a patient with COVID-19 who presented with clot formation and myocarditis. One month after discharge, regarding persistent peripheral/bone marrow hypereosinophilia and clot in echocardiography, fluorescent in situ hybridization (FISH) analysis was done that showed FIP1L1-CHIC2 fusion (PDGFRɑ rearrangement) in 18% of scored cells and PDGFRβ rearrangement in 12% of scored cells, which confirmed HES diagnosis. Clot formation may be a late manifestation of COVID-19 or myocarditis due to COVID-19, or the first manifestation of HES that COVID-19 might provoke in this rare syndrome.
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-021-02317-w