Role of microRNAs in intervertebral disc degeneration (Review)

The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unkn...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2021-08, Vol.22 (2), p.860-860, Article 860
Main Authors: Yang, Fengguang, Wang, Jizu, Chen, Zhixin, Yang, Yuping, Zhang, Wenhui, Guo, Shifang, Yang, Qingshan
Format: Article
Language:English
Subjects:
Apoptosis
Back pain
Binding sites
Cell cycle
Cell growth
Collagen
Degenerative disc disease
Development and progression
Gene expression
Genetic aspects
Health aspects
Inflammation
Intervertebral disk
MicroRNA
MicroRNAs
Physiology
Review
Spinal diseases
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Summary:The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10292