In vitro antiviral activities of ethanol and aqueous extracts of Vietnamese traditional medicinal plants against Porcine Epidemic Diarrhea virus: a coronavirus family member

Porcine epidemic diarrhea virus (PEDV) causes diarrhea in pigs leading to severe illnesses and high mortality rates. The development of medicinal agents to treat PEDV infection is therefore crucial. In this study, antiviral activities against PEDV of ethanol and aqueous extracts of 17 Vietnamese tra...

Full description

Saved in:
Bibliographic Details
Published in:Virusdisease 2021-12, Vol.32 (4), p.797-803
Main Authors: Trinh, Thi Bich Ngoc, Le, Diep Hong, Nguyen, Thanh Thi Kim, Nguyen, Van Tam, Nguyen, Minh Hong, Muller, Marc, Pham, Hai The, Le, Van Phan, Nguyen, Thao Kim Nu
Format: Article
Language:English
Subjects:
Antiviral activity
Biochemistry
Biochemistry, biophysics & molecular biology
Biochimie, biophysique & biologie moléculaire
Biomedical and Life Sciences
Cell Biology
Cell culture
Coronaviruses
Diarrhea
Drug resistance
Epidemics
Ethanol
Flowers & plants
Herbal medicine
Hogs
Life Sciences
Medicinal plants
Microbiology
Minimum inhibitory concentration
Natural products
Plant extracts
Protein Structure
Sciences du vivant
Short Communication
Solvents
Transmissible gastroenteritis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Porcine epidemic diarrhea virus (PEDV) causes diarrhea in pigs leading to severe illnesses and high mortality rates. The development of medicinal agents to treat PEDV infection is therefore crucial. In this study, antiviral activities against PEDV of ethanol and aqueous extracts of 17 Vietnamese traditional medicinal plants were evaluated using the cytopathic effect-based assay. The results showed that 14 out of 17 medicinal plants could inhibit the cytopathic effect of PEDV. The ethanol extract of Stixis scandens was identified as the most active extract with its MIC (minimum inhibitory concentration) being 0.15 μg/mL. Other plant extracts also displayed strong antiviral activity against PEDV, including Anisomeles indica, Pericampylus glaucus and Croton kongensis . The results demonstrate that certain medicinal plants have a high antiviral potential and may serve as a lead to develop novel pharmaceutical agents to cure PED as well as the diseases caused by other coronaviruses.
ISSN:2347-3584
2347-3517
2347-3517
DOI:10.1007/s13337-021-00709-z