CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling

The function of Casein kinase 2 beta ( CSNK2B ) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expressi...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2021-09, Vol.15 (3), p.383-392
Main Authors: Yu, Shijun, Hu, Qingqing, Fan, Kailing, Yang, Chen, Gao, Yong
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Casein
Casein kinase II
Cell Biology
Cell growth
Cell proliferation
Cell viability
Colorectal cancer
Colorectal carcinoma
CSNK2B
DNA microarrays
Gene expression
Immunohistochemistry
Kinases
Life Sciences
mTOR
Research Article
Signal transduction
TOR protein
Tumorigenesis
Western blotting
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Summary:The function of Casein kinase 2 beta ( CSNK2B ) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC.
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-021-00619-1