Variants in AGTR2 gene in Maya people with COVID-19

•Mexico is the fourth place in lethality for COVID-19 infection.•A variant located in AGTR2 gene was associated to T2DM in Maya from Yucatan.•People from Yucatan have a higher risk of lethality among Mexicans.•AGTR2 is highly expressed in lung.•An AGTR2 agonist is under study to fight against lethal...

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Bibliographic Details
Published in:Gene 2021-08, Vol.795, p.145794-145794, Article 145794
Main Authors: Totomoch-Serra, Armando, Domínguez-Cruz, Miriam Givisay, Manterola, C., Muñoz, Maria de Lourdes
Format: Article
Language:English
Subjects:
AGTR2 gene
Angiotensin II Receptor Type 2
C21 drug
Covid-19
COVID-19 - genetics
Diabetes mellitus
Diabetes Mellitus, Type 2 - genetics
Genetic Predisposition to Disease
Humans
Indigenous Peoples - genetics
Letter to the Editor
Maya population
Mexico
Pilot GWAS study
Polymorphism, Single Nucleotide
Receptor, Angiotensin, Type 2 - genetics
SARS-CoV-2
Single nucleotide polymorphism
Yucatan
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Summary:•Mexico is the fourth place in lethality for COVID-19 infection.•A variant located in AGTR2 gene was associated to T2DM in Maya from Yucatan.•People from Yucatan have a higher risk of lethality among Mexicans.•AGTR2 is highly expressed in lung.•An AGTR2 agonist is under study to fight against lethality in COVID-19 infection.
ISSN:0378-1119
1879-0038
1879-0038
DOI:10.1016/j.gene.2021.145794