Biomarkers in Different Asthma Phenotypes

Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease's specific characteristics-biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify...

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Bibliographic Details
Published in:Genes 2021-05, Vol.12 (6), p.801
Main Authors: Popović-Grle, Sanja, Štajduhar, Anamarija, Lampalo, Marina, Rnjak, Dina
Format: Article
Language:English
Subjects:
Asthma
Asthma - blood
Asthma - metabolism
Asthma - pathology
Asthma - urine
Biomarkers
Biomarkers - blood
Biomarkers - metabolism
Biomarkers - urine
Chronic obstructive pulmonary disease
Cytokines
Disease
Gene expression
Genomes
Genotype & phenotype
Humans
MicroRNAs
Patients
Phenotype
Phenotypes
Precision medicine
Respiratory diseases
Review
Sputum - metabolism
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Summary:Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease's specific characteristics-biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify patients, which became especially important with the introduction of biologicals in asthma treatment. Usage of biomarkers and an understanding of the underlying pathobiological mechanisms lead to the definition of endotypes. Asthma can be broadly divided into two endotypes, T2-high and T2-low. The right combination of various biomarkers in different phenotypes is under investigation, hoping to help researchers and clinicians in better disease evaluation since theindividual approach and personalized medicine are imperative. Multiple biomarkers are superior to a single biomarker.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12060801