Effect of Copper Sulphate and Cadmium Chloride on Non-Human Primate Sperm Function In Vitro

In order to address the large percentage of unexplained male infertility in humans, more detailed investigations using sperm functional tests are needed to identify possible causes for compromised fertility. Since many environmental and lifestyle factors might be contributing to infertility, future...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-06, Vol.18 (12), p.6200
Main Authors: Hardneck, Farren, de Villiers, Charon, Maree, Liana
Format: Article
Language:English
Subjects:
Animals
Bisphenol A
Cadmium
Cadmium Chloride
Copper Sulfate
Diet
Fertility
Functional testing
Galvanized steel
Heavy metals
Humans
In vitro fertilization
Infertility
Male
Male reproductive system
Metal concentrations
Motility
Pregnancy
Primates
Quality standards
Reproductive health
Reproductive technologies
Sperm
Sperm Motility
Spermatozoa
Sulfates
Toxicology
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Summary:In order to address the large percentage of unexplained male infertility in humans, more detailed investigations using sperm functional tests are needed to identify possible causes for compromised fertility. Since many environmental and lifestyle factors might be contributing to infertility, future studies aiming to elucidate the effect of such factors on male fertility will need the use of appropriate research models. The current study aimed to assess the effects of two heavy metals, namely copper sulphate, and cadmium chloride, on non-human primate (NHP) sperm function in order to establish the possibility of using these primate species as models for reproductive studies. Our combined results indicated that the functionality of NHP spermatozoa is inhibited by the two heavy metals investigated. After in vitro exposure, detrimental effects, and significant lowered values ( < 0.05) were obtained for sperm motility, viability and vitality, acrosome intactness, and hyperactivation. These metals, at the tested higher concentrations, therefore, have the ability to impair sperm quality thereby affecting sperm fertilizing capability in both humans and NHPs.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18126200