Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-06, Vol.22 (12), p.6392
Main Authors: Suvorov, Nikita, Pogorilyy, Viktor, Diachkova, Ekaterina, Vasil’ev, Yuri, Mironov, Andrey, Grin, Mikhail
Format: Article
Language:English
Subjects:
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial infections
Biofilms
Chlorophyll
Cytotoxicity
Drug resistance
Efficiency
Endangered & extinct species
Gram-negative bacteria
Gram-positive bacteria
Heterocyclic compounds
Light
Membranes
Metabolism
Microorganisms
Permeability
Photodynamic therapy
Reactive oxygen species
Review
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Summary:The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22126392