Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular funct...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2021-08, Vol.162 (8), p.1
Main Authors: Aikins, Ato O, Nguyen, Dianna H, Paundralingga, Obed, Farmer, George E, Shimoura, Caroline Gusson, Brock, Courtney, Cunningham, J Thomas
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin - physiology
Argipressin
Blood Pressure
Blood Volume
Cardiovascular Diseases - etiology
Cardiovascular system
Cardiovascular System - metabolism
Endocrinology
Heart failure
Hormones
Humans
Hypertension
Hypothalamo-Hypophyseal System - metabolism
Mini-Reviews
Natriuresis
Neurons
Neuroplasticity
Neurosecretory cells
Oxytocin
Oxytocin - physiology
Pathophysiology
Pituitary (posterior)
Receptors, Oxytocin - metabolism
Receptors, Vasopressin - metabolism
Sex Characteristics
Vasopressin
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Summary:Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.
ISSN:0013-7227
1945-7170
DOI:10.1210/endocr/bqab082