Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study

Patients that undergo bariatric surgery experience weight loss and a reduction in the plasma levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We used the Israeli national bariatric registry, which includes demographic, clinical, and biochemical data...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2021-06, Vol.10 (12), p.2724
Main Authors: Azulai, Shira, Grinbaum, Ronit, Beglaibter, Nahum, Eldar, Shai Meron, Rubin, Moshe, Carmi, Shai, Ben-Haroush Schyr, Rachel, Romano-Zelekha, Orly, Ben-Zvi, Danny
Format: Article
Language:English
Subjects:
Age
Bile
Body mass index
Clinical medicine
DNA methylation
Enzymes
Ethnicity
Gastrointestinal surgery
Gene expression
Hypertension
Liver
Metabolism
Obesity
Plasma
Population
Regression analysis
Variables
Weight control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients that undergo bariatric surgery experience weight loss and a reduction in the plasma levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We used the Israeli national bariatric registry, which includes demographic, clinical, and biochemical data on 19,403 patients, of which 1335 patients had two-year follow-up data on ALT, AST, A1C, and BMI, to test the dependence of the reduction in the levels of ALT and AST on weight loss. The data were analyzed using regression models, retrospective matching, and time course analyses. Changes in liver enzymes did not correlate with change in BMI, and linear regression models did not demonstrate that the change in ALT and AST values were dependent on pre-operative levels of BMI or the extent of weight loss. ALT and AST levels were reduced two years after surgery compared with a cohort of retrospectively matched patients for ethnicity, sex, age, BMI, and A1C. Finally, patients who regained weight displayed a reduction in levels of liver enzymes. Our results suggest that bariatric surgery affects AST and ALT levels via weight loss dependent and independent mechanisms. Mechanistic studies that will identify the nature of this effect and the clinical relevance of ALT and AST levels to the post-bariatric liver function are warranted.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10122724