Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

Silver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition to their antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage and show potent anticancer properties in both mu...

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Published in:Materials 2021-06, Vol.14 (12), p.3383
Main Authors: Krzyzanowski, Damian, Kruszewski, Marcin, Grzelak, Agnieszka
Format: Article
Language:English
Subjects:
ABC transporters
Anticancer properties
Apoptosis
Binding
Cancer
Cell culture
Cell cycle
Cytotoxicity
Experiments
Fungicides
Gene expression
Kinases
Mitochondria
Nanomaterials
Nanoparticles
Nanotechnology
Nucleic acids
Proteins
Quantum dots
Reagents
RNA polymerase
Silver
Toxicity testing
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cited_by cdi_FETCH-LOGICAL-c383t-c41962ebbf1708c2b3a79be3efcf22ecbdf7350593a921cfc002650f8ea189b43
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creator Krzyzanowski, Damian
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description Silver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition to their antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage and show potent anticancer properties in both multidrug resistance (MDR) and sensitive tumors. The MDR phenomenon, caused by the presence of ATP-binding cassette (ABC) proteins, is responsible for the failure of chemotherapy. Thus, investigating the influence of widely used AgNPs on ABC transporters is crucial. In the present study, we have examined the cytotoxicity of silver nanoparticles of a nominal size of 20 nm (Ag20) on the cell lines of different tissue origins. In addition, we have checked the ATP-binding cassette transporters’ activity and expression under AgNP exposure. The results indicate that Ag20 shows a toxic effect on tested cells, as well as modulating the expression and transport activity of ABC proteins.
doi_str_mv 10.3390/ma14123383
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subjects ABC transporters
Anticancer properties
Apoptosis
Binding
Cancer
Cell culture
Cell cycle
Cytotoxicity
Experiments
Fungicides
Gene expression
Kinases
Mitochondria
Nanomaterials
Nanoparticles
Nanotechnology
Nucleic acids
Proteins
Quantum dots
Reagents
RNA polymerase
Silver
Toxicity testing
title Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines
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