The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous s...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-06, Vol.22 (12), p.6632
Main Authors: Wojciechowicz, Tatiana, Billert, Maria, Jasaszwili, Mariami, Strowski, Mathias Z., Nowak, Krzysztof W., Skrzypski, Marek
Format: Article
Language:English
Subjects:
Adipose tissue
Analgesics
Animal behavior
Anorexia
Anxiety
Appetite
Beta cells
Biological effects
Brain
Central nervous system
Energy balance
Energy metabolism
Food
G protein-coupled receptors
Glucose
Homeostasis
Hypothalamus
Kinases
Ligands
Lipids
Literature reviews
Metabolism
Narcotics
Neuropeptides
Pain
Pancreas
Peptides
Review
Sleep
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Summary:Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22126632