Hypotension and adverse neurodevelopmental outcomes among children with multiple exposures to general anesthesia: Subanalysis of the Mayo Anesthesia Safety in Kids (MASK) Study

Background The potential adverse effects of exposures to general anesthesia on the developing human brain remain controversial. It has been hypothesized that hypotension accompanying anesthesia could be contributory. We hypothesized that among children exposed to multiple anesthetics prior to age 3,...

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Bibliographic Details
Published in:Pediatric anesthesia 2021-03, Vol.31 (3), p.282-289
Main Authors: Gleich, Stephen J., Shi, Yu, Flick, Randall, Zaccariello, Michael J., Schroeder, Darrell R., Hanson, Andrew C., Warner, David O., Vutskits, Laszlo
Format: Article
Language:English
Subjects:
Anesthesia, General - adverse effects
anesthetic neurotoxicity
Blood Pressure
Child
Child, Preschool
children
General anesthesia
Humans
Hypotension
Hypotension - chemically induced
Hypotension - epidemiology
Learning disabilities
neurodevelopment
Prospective Studies
Retrospective Studies
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Summary:Background The potential adverse effects of exposures to general anesthesia on the developing human brain remain controversial. It has been hypothesized that hypotension accompanying anesthesia could be contributory. We hypothesized that among children exposed to multiple anesthetics prior to age 3, children developing adverse neurodevelopmental outcomes would be more likely to have intraoperative hypotension. Methods Two previously published study cohorts were utilized for analysis: the retrospective and prospective Mayo Anesthesia Safety in Kids cohorts. The two lowest consecutive systolic blood pressure measurements were ed and standardized by calculating a z‐score for noninvasive blood pressure reference ranges for children. The lowest systolic blood pressure z‐score (continuous variable) and intraoperative hypotension (lowest systolic blood pressure z‐score
ISSN:1155-5645
1460-9592
DOI:10.1111/pan.14106